“After adding epinephrine, oxybuprocaine was much faster, reaching its maximal blockade, than proxymetacaine or lidocaine (P < 0.01).”
“Coadministration of proxymetacaine, oxybuprocaine , or lidocaine with epinephrine produced a synergistic analgesic effect and prolonged the cutaneous analgesic effect.”
“The use of epinephrine augmented the potency and prolonged the duration of proxymetacaine, oxybuprocaine , and lidocaine as an infiltrative anesthetic.”