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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epinephrine
drug:
Atipamezole
Research Papers that Mention the Interaction
“Functionally, in comparison with yohimbine, an almost threefold lower concentration of atipamezole inhibited adrenaline (5 microM)-induced platelet aggregation.”
Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine.“Significant analgesic effects were noted for at least 4 h. The analgesic effect of intraspinal dexmedetomidine or epinephrine was blocked by systemic pretreatment with the alpha 2-adrenoceptor antagonists, yohimbine and atipamezole , but not with the alpha 1-adrenoceptor antagonist, prazosin.”
Spinal administration of adrenergic agents produces analgesia in amphibians.“Central administration of atipamezole also decreased the AD of epinephrine , while L-659,066, even if administered centrally, did not affect the AD of epinephrine in the presence of halothane.”
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