Possible Interaction: Epinephrine and Ascorbate

“For example, ascorbate rapidly reduces cytochrome b561 from adrenal medullary chromaffin vesicles.”

“The effect of ascorbate was largely due to the fact that it increased the phosphorus metabolism of the adrenals of rats maintained at room temperature.”

“ Ascorbate and adrenaline were highly synergistic in their effects, provided that the ascorbate was present from the start of culture; the response to adrenaline strongly reflected the degree of ascorbate stimulation.”

“The epinephrine and norepinephrine contents of chromaffin cell cultures supplemented with ascorbate for 7 days were increased approximately 10% compared to cultures without added ascorbic acid; ascorbate had no effect on chromaffin cell opioid peptide levels.”

“When compared to adrenal enzyme activities in animals on high dietary levels of ascorbate, the adrenals of animals on 2.4 mg of ascorbate per day expressed 50% increase in the activities of acid phosphatase, arylsulfatase A, and arylsulfatase B (p less than 0.02).”

“ Ascorbate (0.5 mM) inhibited ACTH-induced cyclic [14C]AMP formation in adrenal cells isolated from Vitamin E-deficient rats but had no effect in the control cells.”

“Reducing agents ascorbate , sodium bisulfite) diminished the effects of epinephrine , but did not alter the effects of adrenochrome.”

“ Epinephrine inhibited lipid peroxidation produced by ascorbate.”