Possible Interaction: Epinephrine and Alpha Adrenergic Agent

“Hydergine and other alpha 2-adrenergic antagonists block the specific aggregant action of adrenaline as well as the synergic effect in the presence of PAF-acether.”

“Both short- and long-term administration of alpha adrenergic blockade depressed the glucagon response to epinephrine infusion.”

“ Epinephrine and other agonists with alpha-effects inhibited sequestration through a specific alpha 1-adrenergic , i.e. prazosin-sensitive, mechanism.”

“ Epinephrine and other adrenergic agonists inhibit autophagic sequestration through a prazosin-sensitive, alpha 1-adrenergic mechanism.”

“How much the desensitization of alpha 1-adrenergic receptor-mediated responses contribute to the therapeutic action of epinephrine in the eye remains to be determined.”

“ Epinephrine in addition to inducing this type of desensitization (through protein kinase C) leads to a further refractoriness of the cells towards alpha 1-adrenergic agonists.”

“ Alpha adrenergic activity was demonstrated as substantial cerebral vasoconstriction in response to infusions of l-norepinephrine and epinephrine ; cerebral blood flow (CBF) was decreased by mean values of 25% and 29%, respectively, with calculated increases in CVR of 82% and 62%, respectively.”

“The contractile responses to epinephrine and norepinephrine were blocked by alpha adrenergic blocking agents, whereas atropine blocked the response to acetylcholine.”

“The thrombohemorrhagic lesions produced by ScCl3 plus epinephrine are regularly prevented by pretreatment with alpha adrenergic blocking agents, but not by a series of antihistaminics, antiserotonins or anticoagulants.”