Possible Interaction: Epinephrine and Adrenocorticotropic Hormone

“During the treatment period all adrenal androgens and progestins showed a significant increase in their response to ACTH , while the cortisol response decreased significantly.”

“It apparently reflects the inhibition of glycogen breakdown; concomitant rises in plasma adrenaline and ACTH probably reflect counter-regulatory mechanisms.”

“Interestingly, expression of MC2R and MRAP in the undifferentiated zone would support the notion that ACTH may play an important role in adrenal cell differentiation and maintenance.”

“Thus, in addition to glucocorticoids, ACTH stimulates formation of adrenal androgens , which are known to induce transforming growth factor beta (TGF-beta) secretion.”

“Intracerebroventricular infusion of epinephrine and norepinephrine stimulated ACTH and prolactin secretion.”

“ ACTH … total adrenal HL activity from 3.7 ± 0.5 milliunits to 34.0 ± 17.2 milliunits, as well as adrenal SR-BI mRNA from 2.… uptake by adrenals was also significantly increased from 0.58 ± 0.11% of injected dose to 7.24 ± 1.58% of injected dose.”

“After injection of ACTH, adrenal cortisol and corticosterone concentrations were stimulated by almost 40- and threefold, respectively, whereas the content of C-21 steroid precursors, namely pregnenolone, 17-hydroxypregnenolone, progesterone, and 17-hydroxyprogesterone, was stimulated by two- to 10-fold.”

“ ACTH stimulates … in adrenal cells (Y-1 mouse adrenal tumour cells and cultured bovine fasciculata cells) and this effect of the trophic hormone is inhibited by cytochalasins, … DNase I suggesting that the response to ACTH requires a pool of monomeric (G-) actin that can be polymerized to F-actin.”

“ Adrenal activity was characterized by significant hypercorticism, but also by a relative decrease of the responsiveness to ACTH.”

“Several known naturally occurring substances including vasopressin, oxytocin, norepinephrine, epinephrine , and angiotensin II are found to stimulate ACTH secretion.”