Possible Interaction: Epinephrine and Adrenergic Antagonists

“Animal experiments proved that the simultaneous administration of adrenaline with an α-adrenergic blockade provoked a fall in blood pressure; this phenomenon is called “adrenaline reversal.””

“Avoiding epinephrine and administering β-adrenergic blockers may protect the catecholamine-sensitized heart early during resuscitation in butane exposure cases.”

“ Adrenal blocking drugs suppress adrenal cortisol production via inhibition of steroidogenic enzymes.”

“To the Editor .—In a recent commentary, Brummett 1 drew attention to a common, yet potentially life-threatening, drug interaction between nonselective β-adrenergic blockers and epinephrine.”

“In the presence of β-adrenergic blockade , norepinephrine and epinephrine decreased cyclic [ 14 C]AMP below control values.”

“This effect of epinephrine is in turn inhibited by the α-adrenergic antagonist , phentolamine, but not by the β-adrenergic antagonist, propranolol.”

“A large dose of epinephrine can be both tapenolytic and adrenolytic.”

“Properly an adrenolytic agent is one which nullifies an important effect of epinephrine , whereas a sympatholytic agent is one which nullifies sympathetic nerve transmission, usual reference being to adrenergic pathways controlling blood vessels and usual site of action being at the end organ.”

“Propranolol (non-selective β-adrenergic blocker) and butoxamine (selective β2-adrenergic blocker ) significantly (but not totally) reversed the inhibitory action of ADR on cell proliferation.”

“In the intermediate NTS, release of adrenaline from adrenergic nerve terminals seems to act hypertensive.”