Possible Interaction: Epigallocatechin Gallate and Vitamin C

“ Ascorbic acid eliminates the disruptive role of native EGCG on the fibrils, suggesting that oxidation is a prerequisite in fibril disruption.”

“The presence of vitamin C , amino acids and other micronutrients could enhance inhibitory effect of epigallocatechin gallate (EGCG) on secretion of MMPs.”

“Conversely, the co‐incubation of EGCg with borate or ascorbic acid significantly diminished the EGCg inhibition.”

“The results suggest that the combination of TF3 with AA or EGCG with AA enhances their anticancer activity.”

“ Ascorbic acid was able to enhance the antioxidant activity of EGCG by decreasing the intracellular oxidative stress according to fluorographic analysis of oxidative stress.”

“In conclusion, the combination of EGCG and ascorbic acid can strongly suppress the proliferation and metastasis of liver cancer cells, possibly with a mechanism associated with the scavenging of reactive oxygen species.”

“On the other hand, addition of EGCG was able to increase the cytotoxicity of Cd and to decrease the protective effect of l -ascorbic acid against Cd.”

“Administration of EGCg (500 mg/kg) to rats increased plasma EGCg (4μmol/L as free form) and ascorbic acid (1.7-fold), as well as ORAC (1.2-fold) and FRAP (3-fold) values.”

“Combinations of AA plus EGCG or AA plus CA showed a further protective effect.”

“ EGCG brought about an augmentation in the activities of enzymic antioxidants like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose‐6‐phosphate dehydrogenase and improved the non‐enzymic antioxidants like tocopherol, ascorbic acid and glutathione.”

“Including 30 mg AA in 250 mL of tea beverage significantly (p<0.05) increased catechin recovery of EGC, EGCG , EC, and ECG to 74, 54, 82, and 45% respectively.”