Possible Interaction: Epigallocatechin Gallate and Uridine Triacetate

“Discussion: In this study, we show that EGCG enhances the clearance of AD-relevant phosphorylated tau species in primary neurons.”

“Taken together, these results demonstrate that EGCG has the ability to increase the clearance of phosphorylated tau species in a highly specific manner, likely through increasing adaptor protein expression.”

“This study assessed whether EGCG could also alter tau clearance.”

“We show that (−)‐epigallocatechin gallate (EGCG), a green tea polyphenol that was previously found to reduce Aβ aggregation, inhibits the aggregation of tau K18ΔK280 into toxic oligomers at ten‐ to hundred‐fold substoichiometric concentrations, thereby rescuing toxicity in neuronal model cells.”

“In … how EGCG can … prevent Tau aggregation: (i) in binding Tau in its phosphorylation region with an affinity of the same order of magnitude than kinases (0.5 … to the protein and (ii) in modifying the 3D-structure of Tau whose preferential conformation changes in the presence of EGCG.”

“ EGCG treatment also prevented the hyperphosphorylation of tau and reversed the decreased synaptic protein marker synaptophysin and postsynaptic density protein 95 in FC and Hip of SAMP8 mice.”

“ EGCG potently inhibited MG-induced advanced glycation endproducts formation in neuroblastoma cells as well modulated the localization of AT100 phosphorylated Tau in the cells.”

“ EGCG decreased the hyperphosphorylation of Tau in hippocampus.”