supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
drug:
Temozolomide
Research Papers that Mention the Interaction
“Furthermore, EGCG enhances the efficacy of anti-glioma therapies, including irradiation, temozolomide , carmustine, cisplatin, tamoxifen, and TNF-related apoptosis-inducing ligand, but reduces the effect of bortezomib.”
Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate on Glioma: A Critical Evaluation of the Literature“Importantly, EGCG treatment significantly downregulated P-glycoprotein expression but not that of ABCG2 or MGMT and simultaneously enhanced sensitivity to TMZ.”
“Immunohistochemical analysis of tumor tissue revealed increased expression levels of GRP78 in temozolomide-treated animals, which was diminished when temozolomide was combined with EGCG.”
“We found that EGCG alone did not provide survival benefit, but significantly improved the existing therapeutic effect of temozolomide , i.e., life extension was substantially greater under combination therapy as compared to temozolomide therapy alone.”
“Conclusions: EGCG preferentially inhibits MGMT and enhances TMZ cytotoxicity in glioblastoma cells rather than in nontumor glial cells.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback