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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Epigallocatechin Gallate and Sunitinib

Research Papers that Mention the Interaction

EGCG enhanced the antiproliferation and VEGF secretion-reducing effects of sunitinib in the three tested cell lines.
EGCG potentially synergizes with sunitinib due to its ability to suppress the IRS/MAPK signaling induced by sunitinib.
In vivo, immunohistochemical analyses demonstrated marked suppression of the IRS/MAPK/p-S6K1 signaling cascade by EGCG , especially after sunitinib treatment.
In vivo, EGCG administration at 4 h after sunitinib treatment resulted in greater tumor shrinkage and antiangiogenesis than with sunitinib alone.
Tumor Biology  •  2015  |  View Paper
1H-NMR spectra indicated an interaction between EGCG and sunitinib , but no new compound was observed by MS.
In this study, we noticed that a precipitate was formed when the solutions of sunitinib and EGCG were mixed under both neutral and acidic conditions.
Our study firstly showed that EGCG interacted with sunitinib and reduced the bioavailability of sunitinib.
Journal of Molecular Medicine  •  2011  |  View Paper