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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epigallocatechin Gallate
drug:
Sunitinib
Research Papers that Mention the Interaction
“ EGCG enhanced the antiproliferation and VEGF secretion-reducing effects of sunitinib in the three tested cell lines.”
“ EGCG potentially synergizes with sunitinib due to its ability to suppress the IRS/MAPK signaling induced by sunitinib.”
“In vivo, immunohistochemical analyses demonstrated marked suppression of the IRS/MAPK/p-S6K1 signaling cascade by EGCG , especially after sunitinib treatment.”
“In vivo, EGCG administration at 4 h after sunitinib treatment resulted in greater tumor shrinkage and antiangiogenesis than with sunitinib alone.”
The green tea polyphenol EGCG potentiates the antiproliferative activity of sunitinib in human cancer cells“1H-NMR spectra indicated an interaction between EGCG and sunitinib , but no new compound was observed by MS.”
“In this study, we noticed that a precipitate was formed when the solutions of sunitinib and EGCG were mixed under both neutral and acidic conditions.”
“Our study firstly showed that EGCG interacted with sunitinib and reduced the bioavailability of sunitinib.”
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