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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
drug:
Simvastatin
Research Papers that Mention the Interaction
“In vitro experiments suggested the inhibitory effect of EGCG on CYP enzymes (IC50: 18.37 ± 1.36 μM, 26.08 ± 1.51 μM for simvastatin and simvastatin acid, respectively).”
“ Simvastatin transport by OATP1B1 and OATP1B3 was also inhibited by EGCG (IC50: 8.68 ± 1.27 μM and 22.67 ± 1.42 μM, respectively).”
“The presently reported novel food–drug interaction between GCG and s imvastatin involves the inhibition of not only CYP450 enzymes but also OATPs by EGCG.”
“The results showed that areas under concentration–time (AUC) curves of simvastatin and simvastatin acid increased by 2.21- and 1.4-fold while the clearance was reduced by 2.29- and 1.4-fold, respectively, when co-administered with EGCG.”
Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats“Furthermore, the combination of EGCG and simvastatin inhibited the proliferation, migration and invasion, and promoted apoptosis significantly compared with single treatment in CAL27 cells.”
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