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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Epigallocatechin Gallate
drug:
Raloxifene
Research Papers that Mention the Interaction
“Experimental trials suggest a synergistic interaction of green tea catechins with tamoxifen or raloxifene in the treatment of estrogen receptor-positive and estrogen receptor-negative breast cancer through estrogen receptor-dependent and -independent mechanisms.”
Interaction of Green Tea Catechins with Breast Cancer Endocrine Treatment: A Systematic Review“Furthermore, these changes were associated with a reduction in the nuclear localization of p65, a major subunit of NF-kappaB. These results demonstrate that the combination of EGCG and raloxifene effectively reduced the mitogenic and survival signaling in MDA-MB-231 cells.”
“Previous study from this laboratory has demonstrated that the combination of EGCG (25 microM) and raloxifene (4 microM) elicits a strong cytotoxic response in MDA-MB-231 human breast cancer cells, which lack the estrogen receptor (ER) and erbB-2/ Her-2 receptor.”
“In conclusion, the synergistic cytotoxicity elicited by the combination of EGCG and raloxifene results from an earlier and greater induction of apoptosis.”
“The combination of 5 microM raloxifene and EGCG was the most effective as it decreased cell number by 96% of control, and time-course studies demonstrated that significant cytotoxicity began 36 h after treatment.”
“We aimed to determine if this effect was enhanced by combining raloxifene with epigallocatechin gallate (EGCG).”
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