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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
drug:
Pancreatic Lipase
Research Papers that Mention the Interaction
“DSC measurement revealed that EGCG analogs decreased the transition midpoint temperature of PL enzyme, suggesting that these compounds reduced PL enzyme thermostability.”
“ EGCG analogs would induce PL self-assembly into complexes and the hydrodynamic radii of the complexes possessed a close relationship with the inhibitory rates.”
“It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC.”
“α-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC.”
Molecular Interactions between (−)-Epigallocatechin Gallate Analogs and Pancreatic Lipase“EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat‐fed control, whereas in vitro, EGCG dose‐dependently inhibited PL (IC50 = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration.”
“In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.”
“epigallocatechin (EGC) and epigallocatechin gallate (EGCG) showed, comparative to others, higher PL inhibitions (IC50, 387.2, 237.3, and 391.2μM respectively).”
Mode of pancreatic lipase inhibition activity in vitro by some flavonoids and non-flavonoid polyphenols.
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