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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Epigallocatechin Gallate
drug:
Paclitaxel
Research Papers that Mention the Interaction
“GRP78 knockdown or EGCG potentiates taxol‐ and vinblastine‐induced activation of pro‐apoptosis arms of the ER stress response, such as JNK phosphorylation, caspase‐7 and PARP cleavage.”
“Treatment with (‐)‐epigallocatechin gallate (EGCG), a known GRP78 inhibitor, synergistically promotes taxol‐ and vinblastine‐induced cell death.”
Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response“Although these concentrations of EGCG are quite high, we found that concentrations of 0.… are in the range of plasma concentrations after administering a single oral dose of EGCG or a green tea extract, markedly enhanced … cell lines to growth inhibition by Taxol , a drug frequently … carcinoma and HNSCC.”
“ Epigallocatechin gallate (EGCG) and tannic acid (TA) are known to increase the aqueous solubility and cellular uptake of the hydrophobic drugs docetaxel, paclitaxel , amphotericin B, curcumin.”
Part 1. Evaluation of epigallocatechin gallate or tannic acid formulations of hydrophobic drugs for enhanced dermal and bladder uptake or for local anesthesia effects.“Additionally, the combination of epigallocatechin‐3‐gallate and paclitaxel significantly enhanced the later anticancer efficacy.”
“Thus, the efficacy of EGCG and paclitaxel combination treatment seems to be schedule-dependent.”
Schedule-Dependent Effect of Epigallocatechin-3-Gallate (EGCG) with Paclitaxel on H460 Cells“Isobolograms generated from the data clearly indicated that EGCG in combination with paclitaxel or docetaxel had an additive effect in blocking tumor cell growth.”
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