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Last Updated: 2 years ago

Possible Interaction: Epigallocatechin Gallate and Leptin

Research Papers that Mention the Interaction

EGCG was found to inhibit the induction of key adipogenic biomarkers, including lipoprotein lipase, adiponectin, leptin , fatty acid synthase, and fatty acid binding protein 4.
Molecules  •  2021  |  View Paper
Treatment with EGCG significantly decreased serum calcium, urinary calcium, body weight and body fat, and increased leptin levels in mice with secondary osteoporosis.
Molecular medicine reports  •  2018  |  View Paper
Furthermore, we demonstrate that EGCG downregulates insulin-like peptide 5 and phosphoenolpyruvate carboxykinase, major regulators of glucose metabolism, as well as the Drosophila homolog of leptin , unpaired 2.
Oncotarget  •  2015  |  View Paper
EGCG treatment attenuated leptin expression and diminished neointimal formation.
In summary, balloon injury induces leptin expression in the carotid artery of rats, and EGCG inhibits leptin expression through the JNK/AP-1 pathway and also attenuates neointimal formation.
Journal of agricultural and food chemistry  •  2014  |  View Paper
Treating these mice with EGCG also caused an increase in the serum level of IGFBP-3 while conversely decreasing the serum levels of IGF-I, insulin, triglyceride, cholesterol, and leptin.
Cancer Prevention Research  •  2008  |  View Paper
Conclusions: Considering the high prevalence of obesity, this observation provides a rationale for use of curcumin, quercetin and EGCG as antagonists of leptin in the treatment of obese breast cancer patients.
Increase in ERK1/2 phosphorylation in response to leptin was reduced by the addition of quercetin, curcumin and EGCG.
Medicines  •  2017  |  View Paper
EGCG additionally reduced leptin levels (p < 0.01) while GrTP and sulfasalazine had no effect on leptin levels (p < 0.05).
Front. Immunol.  •  2013  |  View Paper