Possible Interaction: Epigallocatechin Gallate and Interleukin-10

“ EGCG treatment significantly enhanced the number of Foxp3-expressing Tregs and IL-10 production in vitro (P < 0·05) in both groups.”

“Thus, in part, EGCG enhances the functionality of Tregs, i.e. IL-10 production and number by suppressing the NF-κB signalling pathway via inducing epigenetic changes.”

“Most importantly, mature DCs treated with EGCG inhibited stimulatory activity toward allogeneic T cells while secreting high amounts of IL-10.”

“The results showed that administration of EGCG significantly decreased AHR and OVA specific IgE in the serum, increased IL-10 levels in the BALF, serum, and splenocyte culture supernatant, and the frequency of CD4+CD25+Foxp3+Treg cells in the splenocytes in asthmatic mice.”

“At 20μM dilution, both CHX and EGCG significantly increased the secretion of IL-1β, IL-10 , IL-12, KC, MIP-1α, IFN-γ and IL-6 (p<0.05).”

“In addition, TNF-α and IL-10 levels in EPI and adiponectin levels were higher in the CD + EGCG group than in the CD + placebo group.”

“ EGCG also prevented the seawater aspiration-induced increase of TNF-α and IL-1 and decrease of IL-10 in NR8383 cell line.”

“The results showed that EGCG pretreatment significantly improved hypoxemia and histopathologic changes, alleviated pulmonary edema and lung vascular leak, reduced the production of TNF-α and IL-1, and increased the production of IL-10 in seawater aspiration-induced ALI rats.”

“Furthermore, EGCg inhibited SEB-induced TNF-α and IFN- γ production and IL-2, IFN- γ, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose-dependent manner.”