Possible Interaction: Epigallocatechin Gallate and Green Tea Extract

“A significant dose-dependent elevation was found for (-)-epicatechin-3-gallate (ECG ) (p<0.001, trend test) and (-)-epigallocatechin-3-gallate (EGCG) (p<0.05, trend test) concentrations in plasma at both 1-month and 3-months after intervention with GTPs.”

“However, the use of different doses of green tea extracts and EGCG makes it difficult to reach consistent conclusions for different populations.”

“Intake of EGCG with green tea infusions and GTE-based beverages is up to about 450mg EGCG/person/day in Europe and higher in Asia.”

“The addition of GTE to the enzyme reaction resulted in a significant increase in degallated catechins, including gallic acid, a product of the tannase reaction (314.5-4076.0 µg mL(-1)) and a reduction in epigallocatechin gallate (EGCG).”

“Both the green tea extract and epigallocatechin‐3‐gallate (EGCG) dose‐ and time‐dependently increased the transepithelial electrical resistance (TER) of a gingival keratinocyte model and decreased the permeability of the cell monolayer to fluorescein isothyocyanate‐conjugated 4.4‐kDa dextran.”

“However, EGCG alone was about 3-5-fold less effective than GTE.”

“These mechanisms together with others, may contribute to the overall chemopreventive function of EGCG itself as well as the GTP.”

“ GTP at 1000 μg/ml and EGCG (68 and 680 μg/ml) significantly affected cell viability.”

“In conclusion, total GTP exerted greater inhibitory effects than purified EGCG on adipogenesis through down-regulating the adipogenic factor C/EBPα, SREBP-1c and PPARγ expression.”

“Epigallocatechin gallate (EGCG), a major component of tea catechins, also enhanced endurance capacity, suggesting that the endurance-improving effects of GTE were mediated, at least in part, by EGCG.”

“It seems that there is a big differ-ence in the vascular effect between GTE and EGCG.”