Possible Interaction: Epigallocatechin Gallate and Glatiramer

“Interestingly, the neuroprotective effect of EGCG was abolished when GA was applied in combination.”

“To elucidate how a single dose of GA may interfere with EGCG , we focused on the anti-inflammatory, iron chelating and anti-oxidant properties of EGCG.”

“We first assessed how a treatment with a single dose of GA together with daily application of EGCG may modulate EAE.”

“We previously demonstrated that epigallocatechin-3-gallate (EGCG) synergizes with the immunomodulatory agent glatiramer acetate (GA) in eliciting anti-inflammatory and neuroprotective effects in the relapsing-remitting EAE model.”

“ EGCG and GA together led to increased protection from glutamate- and TRAIL-induced neuronal cell death in vitro.”

“Here we show that the combination therapy of Glatiramer acetate (GA), an immunomodulatory MS therapeutic, and the neuroprotectant epigallocatechin-3-gallate (EGCG), the main phenol in green tea, have synergistic protective effects in vitro and in the EAE model.”

“Neuroprotective and neuroregenerative effects could be translated in the in vivo model, where combination treatment with EGCG and GA significantly delayed disease onset, strongly reduced clinical severity, even after onset of symptoms and reduced inflammatory infiltrates.”

“Conclusion In RRMS, oral EGCG add-on to GA was not superior to placebo in influencing MRI and clinical disease activity over 18 months.”