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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
supplement:
Folate
Research Papers that Mention the Interaction
“ Green tea catechins (GTC) have been shown to inhibit the activities of enzymes involved in folate uptake.”
Greeen tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study.“The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been reported to act as a cancer preventive agent through folate pathway inhibition in experimental studies.”
“We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG , then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes.”
“Rescue experiments using leucovorin and hypoxanthine-thymine medium were the first indication that epigallocatechin-3-gallate could disturb the folate metabolism within cells.”
“We demonstrate that by disturbing the folate metabolism, EGCG can inhibit ergosterol production.”
Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans.
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