Possible Interaction: Epigallocatechin Gallate and Epigallocatechin

“And epigallocatechin gallate (EGCG), a bioactive component of green tea, by binding to CD11b, expressed on CD8(+) cytotoxic T cells, inhibited their migratory ability, one possible mechanism of the antiallergic activity of EGCG.”

“ECg, EGC , and a catechin mixture, in addition to EGCg , significantly decreased cell viability.”

“ EGCG and CG also inhibited the invasion and migration, with EGC exhibiting a lower efficacy.”

“The amounts of EGCg required to inhibit by both criteria was reduced 10 times by combination with inactive catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) or (-)-epicatechin-3-gallate (ECG).”

“All the above parameters were significantly reversed with EGCG treatment, especially in the EGCG100 group.”

“ EGCG potently inhibited proton currents with an IC(50) of 3.7 μM. Other tea catechins, (-)-epigallocatechin , (-)-epicatechin and (-)-epicatechin-3-gallate, were far less potent than EGCG.”

“Although other polyphenols present in GTPP, particularly epigallocatechin and epicatechin, lack this activity, they synergistically promoted this action of EGCG.”

“Furthermore, the combined treatment of EGCG (5 microM) and EGC (5 microM) showed a significant time-dependent suppression of the increased intracellular ROS levels 15 min after the addition of FK506, as well as on caspase activation.”

“Similarly, the combined treatment with 5 microM EGC and 5 microM of C, EC, EGCG or ECG also reduced the cytotoxicity.”

“The effect of (−)-epigallocatechin was weaker than that of (−)-epigallocatechin gallate.”

“In addition, the inhibitory activity of GCG was greater than that of EGCG , which is well known to be an antiallergic constituent in tea.”