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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
drug:
Docetaxel
Research Papers that Mention the Interaction
“In addition, EGCG significantly and synergistically enhanced the antitumor effects of the clinical drug, docetaxel , in CL1-5 cells.”
EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest.“ Epigallocatechin gallate (EGCG) and tannic acid (TA) are known to increase the aqueous solubility and cellular uptake of the hydrophobic drugs docetaxel , paclitaxel, amphotericin B, curcumin.”
Part 1. Evaluation of epigallocatechin gallate or tannic acid formulations of hydrophobic drugs for enhanced dermal and bladder uptake or for local anesthesia effects.“Isobolograms generated from the data clearly indicated that EGCG in combination with paclitaxel or docetaxel had an additive effect in blocking tumor cell growth.”
Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors.
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