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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Epigallocatechin Gallate
drug:
Cpt-11
Research Papers that Mention the Interaction
“In conclusion, EGCG was found to inhibit the transport of CPT-11 and SN-38 into the biliary elimination and their half-lives in plasma could be substantially prolonged.”
“The blood to bile distribution ratio (AUC(bile)/…(blood)) was significantly reduced after group coadministration of EGCG , it can be seen that … bile efflux transport system of CPT-11 and SN-38 may be markedly reduced by the treatment of EGCG which plays the role of P-gp inhibitor.”
“The pharmacokinetic data indicate that the area under the plasma concentration-time curves (AUC) of CPT-11 and SN-38 were increased by 57.7 and 18.3%, and AUC in bile were decreased by 15.8 and 46.8%, respectively, for the group pretreated with EGCG.”
Food-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38.
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