Possible Interaction: Epigallocatechin Gallate and Celecoxib

“The synergistic enhancements of apoptosis and GADD153 gene expression in human non‐small cell lung cancer cells by the combination of EGCG and celecoxib were mediated through the activation of the MAPK signaling pathway.”

“ Celecoxib and EGCG synergistically reduced IL-1-induced production of pro-inflammatory IL-6 and pro-angiogenic IL-8 to 23-50%.”

“Thus, in Colo357, EGCG synergistically boosts celecoxib-mediated effects and reduces the levels of celecoxib required to elicit beneficial effects on tumorigenic mediators by a factor of ten.”

“We found that co-incubation of Colo357 with celecoxib and EGCG synergistically diminished metabolic activity via apoptosis induction and down-regulated release of pro-angiogenic vascular endothelial growth factor (VEGF) and invasiveness-promoting matrix metalloproteinase (MMP)-2 to a maximum of 30%.”

“Judging by upregulation of GADD153, only cotreatment with EGCG plus celecoxib synergistically induced apoptosis of PC‐9 cells.”

“We specifically looked for induction of apoptosis and expression of apoptosis related genes, with emphasis … damage‐inducible 153 (GADD153) gene, in human lung cancer cell line PC‐9: Cotreatment with EGCG … celecoxib strongly induced the expression of both GADD153 mRNA level … cells, while neither EGCG nor celecoxib alone did.”

“At sacrifice (19 weeks of age), treatment with both celecoxib (74% inhibition, P<0.01) and EGCG (71% inhibition, P<0.05) significantly inhibited the development of colitis-associated colon tumors.”