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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
drug:
Becaplermin
Research Papers that Mention the Interaction
“Furthermore, EGCG may be used for treatment and prevention of cardiovascular disease through blocking of PDGF-bb signaling.”
Mitogenesis of Vascular Smooth Muscle Cell Stimulated by Platelet-Derived Growth Factor-bb Is Inhibited by Blocking of Intracellular Signaling by Epigallocatechin-3-O-Gallate“Treatment of VSMCs with 10 and 50 microM EGCG resulted in an 80% and a complete inhibition of the PDGF-BB-induced activation of MAP kinase isoforms, respectively.”
“Therefore, we investigated the inhibitory effects of EGCG on RPE cell migration induced by PDGF-BB , an isoform of PDGF, and adhesion by fibronectin.”
“Furthermore, EGCG inhibited TGF-β or PDGF-BB-induced phospho-extracellular signal-regulated kinase (ERK)1/2 MAP kinase and NF-κB activity in SSc fibroblasts.”
“ EGCG blocked PDGF-BB binding to its receptor in a non-competitive manner.”
“ Green tea catechins decreased [3H]thymidine incorporation stimulated with PDGF-BB dose dependently.”
“It has been shown that green tea catechins (GTC) suppress proliferation of vascular smooth muscle cells (VSMCs) and that epigallocatechin-3-gallate (EGCG), which is a major constituent of GTC, selectively inhibits the platelet-derived growth factor-BB (PDGF-BB)-induced intracellular signaling transduction pathway.”
Local delivery of green tea catechins inhibits neointimal formation in the rat carotid artery injury model
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