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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Epigallocatechin Gallate
drug:
Aldesleukin
Research Papers that Mention the Interaction
“Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced SEB-induced proliferation and IL-2 , IFNgamma, and TNFalpha production.”
Immune cell activation and subsequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate.“In the present study, we found that (-)-epigallocatechin-3-gallate (EGCG ) significantly up-regulated the mRNA expression of the Th1/Th2 cytokines including IL-2 , IFN-gamma, IL-5 and IL-13 in Jurkat T cells.”
“Our data show that EGTE administration increased NK cell cytolysis and peritoneal cell phagocytosis, as well as splenocyte proliferation and secretion of IL-2 and IFN-γ.”
Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model“ EGCG treatment decreased the proliferation of donor cells in MLR cultures and secretion of IL-2 and INF-γ.”
“ EGCG increased accumulation of IL-2 but inhibited expression of IL-2R, including all its subunits [IL-2Rα, IL-2/IL-15Rβ, and common γ chain (γc)].”
“ EGCG supplementation resulted in lower IL-2 receptor expression and higher IL-2 accumulation, suggesting an impeded IL-2/IL-2 receptor signaling.”
“The mRNA expression of MIF, TNF-alpha, IFN-gamma, IL-2 and IL-12 p40, but not of IL-4, IL-5 and IL-13 in the lesions was significantly reduced by EGCG (p<0.05).”
“Furthermore, EGCg inhibited SEB-induced TNF-α and IFN- γ production and IL-2 , IFN- γ, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose-dependent manner.”
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