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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Epicatechin
supplement:
Apigenin
Research Papers that Mention the Interaction
“… epicatechin are potent inhibitors of H₂O₂ production by mitochondria from both tissues (IC₅₀ approximately 1-2 μM), even when H₂O₂ production rate …. Although the rate of oxygen consumption was unaffected by concentrations up to 10 μM of these flavonoids, quercetin, kaempferol and apigenin inhibited complex I … than 20% inhibition.”
Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria.
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