Possible Interaction: Ephedrine and Epinephrine

“In an in vitro study ephedrine was found to inhibit platelet aggregation induced by adrenaline and, to some extent, also by ADP.”

“A week of ephedrine produced more profound depression of the beta adrenergic responses to epinephrine with significant differences in the rise in blood glucose and lactate, and the pulse and blood pressure responses.”

“Furthermore, these same responses remained significantly altered when a second epinephrine infusion was performed 36 hours following the last dose of ephedrine.”

“The alterations in the response to epinephrine induced by ephedrine are consistent with the concept of effector cell "subsensitivity," an adaptive response to prolonged excessive stimulation.”

“Aggregation responses to epinephrine were greatly reduced in the presence of commonly used sympathomimetics such as ephedrine , phenylpropanolamine, and racemic amphetamine that have been found in cold remedies, appetite suppressants, or used in the treatment of attention-deficit hyperactivity disorder, respectively.”

“ Adrenaline and ephedrine were required intravenously on repeated occasions on account of symptom-producing hypotension with a systolic pressure as low as 60 mmHg.”

“The pulse rate during the epinephrine infusion following the administration of ephedrine was significantly slower than following the other regimens; the mean blood pressure was higher following ephedrine, but the difference was not statistically significant.”

“Cocaine and ephedrine inhibit the positive inotropic response of the atropinized papillary muscle of the cat to either TMA or epinephrine.”

“Only ephedrine and methoxamine were found to be capable of reversing the epinephrine depressor effect to a pressor effect.”

“A dissimilarity of action between ephedrine, epinephrine is demonstrated.”

“ Ephedrine also blocked the stimulatory effects of epinephrine on rat adenyl cyclase.”

“ Ephedrine and Neosynephrine produce considerably less potassium rise than equipressor doses of epinephrine during cyclopropane anesthesia and usually they fail to produce ventricular tachycardia.”