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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“BACKGROUND Inorganic fluoride is released by the metabolism of enflurane and the increased serum fluoride concentrations may impair renal function.”
Fluoride metabolism in smokers and non-smokers following enflurane anaesthesia.“ Enflurane and even isoflurane may, when used during prolonged operations, also yield anorganic fluoride levels in excess of 50 mumol/l.”
“However, it is the inorganic fluoride that is responsible for the nephrotoxic effect associated with enflurane.”
“Seven patients were exposed to enflurane in a concentration of 200 parts per million for 4 h. A significant increase in the plasma concentration of fluoride was observed.”
“Small amounts of free fluoride ion accumulate during the metabolism of enflurane.”
“Although Ks, ΔAmax, KM and Vmax (NADPH consumption) are similar in magnitude for enflurane and methoxyflurane, the rate of production of fluoride from enflurane is approximately 8-fold less than from methoxyflurane.”
Enflurane and methoxyflurane. Their interaction with hepatic cytochrome P-450 in vitro.
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