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Possible Interaction: Enflurane and Fluorides

supplement:

Fluorides

Research Papers that Mention the Interaction

BACKGROUND Inorganic fluoride is released by the metabolism of enflurane and the increased serum fluoride concentrations may impair renal function.
British journal of anaesthesia  •  2003  |  View Paper
Enflurane and even isoflurane may, when used during prolonged operations, also yield anorganic fluoride levels in excess of 50 mumol/l.
Der Anaesthesist  •  1996  |  View Paper
However, it is the inorganic fluoride that is responsible for the nephrotoxic effect associated with enflurane.
Anesthesia and analgesia  •  1989  |  View Paper
Seven patients were exposed to enflurane in a concentration of 200 parts per million for 4 h. A significant increase in the plasma concentration of fluoride was observed.
Acta anaesthesiologica Scandinavica  •  1985  |  View Paper
Small amounts of free fluoride ion accumulate during the metabolism of enflurane.
Anesthesia and analgesia  •  1983  |  View Paper
Although Ks, ΔAmax, KM and Vmax (NADPH consumption) are similar in magnitude for enflurane and methoxyflurane, the rate of production of fluoride from enflurane is approximately 8-fold less than from methoxyflurane.
Biochemical pharmacology  •  1979  |  View Paper