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“In glycerinated muscle fiber, enflurane shifted the pCa-tension relation to the left in low calcium and suppressed maximally activated tension at high calcium concentration.”
“Because these results eliminate most alternative explanations for this phenomenon, the authors conclude that halothane, and probably also enflurane , increases the fraction of calcium released from the sarcoplasmic reticulum with each heart beat.”
“Halothane and enflurane mainly decrease intracellular calcium availability by a direct effect on sarcoplasmic reticulum, while isoflurane only decreases the transsarcolemnal calcium entry.”
Annales francaises d'anesthesie et de reanimation • 1994 | View Paper
“Of the volatile anesthetics, isoflurane (2.6 vol% or 0.57 mM) and enflurane (4.3 vol% or 1.25 mM) inhibited initial net Ca influx during K depolarization significantly more than halothane (1.7 vol% or 0.50 mM), which had no apparent effect.”
“These observations are consistent with the hypothesis that enflurane may impair calcium handling by the sarcoplasmic reticulum whereas propofol has little, if any, effect at this site.”