Possible Interaction: Enflurane and Calcium Supplement

“In glycerinated muscle fiber, enflurane shifted the pCa-tension relation to the left in low calcium and suppressed maximally activated tension at high calcium concentration.”

“Because these results eliminate most alternative explanations for this phenomenon, the authors conclude that halothane, and probably also enflurane , increases the fraction of calcium released from the sarcoplasmic reticulum with each heart beat.”

“Halothane and enflurane mainly decrease intracellular calcium availability by a direct effect on sarcoplasmic reticulum, while isoflurane only decreases the transsarcolemnal calcium entry.”

“The most curious effect is the increase in ATPase activity and Ca 2 + uptake caused by enflurane.”

“ Enflurane (4.3 vol%) caused a significant reduction in SR Ca content.”

“The effect of enflurane was either potentiated or reduced respectively in the presence of lower or higher calcium concentrations.”

“Both halothane and enflurane decreased the calcium content of sarcoplasmic reticulum (SR) as measured by caffeine-induced calcium release.”

“Caffeine, halothane, enflurane , and isoflurane all decreased the total calcium content of myocytes by 10-70%.”

“ Enflurane altered synaptic transmission in the in vitro rat hippocampal slice preparation and produced seizure-like burst discharges of CA 1 neurones, at vapour concentrations equivalent to those obtained during anaesthesia (2-6 vol%; 0.5-1.5 mmol litre-1).”

“Increasing the extracellular calcium concentration counteracted the negative chronotropic effects of halothane, enflurane , and isoflurane.”