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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Enalapril and Naringenin



Research Papers that Mention the Interaction

In Caco-2 cells, demonstrated to contain minimal CYP3A activity, the permeability coefficient of the prodrugs lovastatin and enalapril was increased in the presence of the active flavonoids kaempferol and naringenin , consistent with inhibition of esterase activity.
Overall, a series of flavonoids present in GFJ are identified as esterase inhibitors, of which kaempferol and naringenin are shown to mediate pharmacokinetic drug interaction with the prodrugs lovastatin and enalapril due to their capability of esterase inhibition.
Drug Metabolism and Disposition  •  2007  |  View Paper