Possible Interaction: Enalapril and Folic Acid

“In a recent issue of the Journal, Qin et al. (3) reported that treatment with enalapril together with folic acid (800 μg/d) reduced the concentration of uric acid and the risk of hyperuricemia in hypertensive patients in comparison to enalapril alone.”

“A total of 15,364 hypertensive Chinese adults were randomly assigned to receive double-blind daily treatment with 10 … mg enalapril alone (n 1⁄4 7679) and were followed for 4.5 y. The combined use of enalapril … folic acid , compared with enalapril alone, significantly … of new-onset hyperuricemia.”

“Xu and colleagues report … daily treatment with enalapril (… folic acid (0.8 mg), compared with daily enalapril alone, reduced the risk of CKD progression by 21% and the rate of …,104 Chinese adults (aged 45–75 years) with hypertension and eGFR ≥30 ml/min/1.73 m at baseline.”

“” Xu and colleagues …, combined daily treatment with enalapril (… folic acid (0.8 mg), compared with daily enalapril alone, reduced the risk of CKD progression by 21% and the rate of …,104 Chinese adults (aged 45–75 years) with hypertension and eGFR ≥30 ml/min/1.73 m at baseline.”

“The CSPPTwas terminated earlywhen800μgof folic acid in combination with 10 mg of enalapril significantly reduced primarystroke incidencecomparedwith theenalapril alone treatment arm.”

“This finding is ….4 Importantly, the folicacid– enalapril combinationwasmore effective in reducing rates of renal dysfunction in individuals with CKD (odds ratio [OR], 0.44; 95% CI, 0.26-… treatment significantly reduced other measures of renal dysfunction in addition to the 21% reduction in risk for theprimaryoutcomecomparedwith theenalapril-onlygroup.”

“CONCLUSIONS AND RELEVANCE Among adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid , compared with enalapril alone, significantly reduced the risk of first stroke.”

“ CONCLUSIONS AND RELEVANCE Among adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid , compared with enalapril alone, significantly reduced the risk of first stroke.”

“In a new study published in the Journal of the American Medical Association, the combination of enalapril and folic acid was reported to reduce the incidence of first stroke when compared with enalapril alone.”

“Conclusion In Chinese adults with hypertension, enalapril plus folic acid reduced incident stroke more than enalapril alone.”

“CONCLUSION As compared to enalapril alone, enalapril combined with folic acid showed a better efficacy in reducing both blood pressure and plasma Hcy level in hypertensive subjects.”

“ CONCLUSION As compared to enalapril alone, enalapril combined with folic acid showed a better efficacy in reducing both blood pressure and plasma Hcy level in hypertensive subjects.”

“CONCLUSION In this sample of adult Chinese hypertensive patients, FA combined with enalapril showed a greater beneficial effect on reduction of FPG in a dose-related fashion than did enalapril alone among subjects with hyperglycemia.”

“ CONCLUSION In this sample of adult Chinese hypertensive patients, FA combined with enalapril showed a greater beneficial effect on reduction of FPG in a dose-related fashion than did enalapril alone among subjects with hyperglycemia.”