Possible Interaction: Enalapril and Folic Acid

“A total of 15,364 hypertensive Chinese adults were randomly assigned to receive double-blind daily treatment with 10 … mg enalapril alone (n 1⁄4 7679) and were followed for 4.5 y. The combined use of enalapril … folic acid , compared with enalapril alone, significantly … of new-onset hyperuricemia.”

“Xu and colleagues report … daily treatment with enalapril (… folic acid (0.8 mg), compared with daily enalapril alone, reduced the risk of CKD progression by 21% and the rate of …,104 Chinese adults (aged 45–75 years) with hypertension and eGFR ≥30 ml/min/1.73 m at baseline.”

“The CSPPTwas terminated earlywhen800μgof folic acid in combination with 10 mg of enalapril significantly reduced primarystroke incidencecomparedwith theenalapril alone treatment arm.”

“Conclusion In this sample of adult hypertensive patients, … of a daily dose of 10 mg of enalapril combined with 0.… of FA had a greater beneficial effect on the serum UA levels than did that of … of enalapril alone in patients with either an elevated UA concentration or HUA.”

“In a new study published in the Journal of the American Medical Association, the combination of enalapril and folic acid was reported to reduce the incidence of first stroke when compared with enalapril alone.”