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Last Updated: 2 months ago

Possible Interaction: Emodin and Zidovudine

supplement:

Emodin

Research Papers that Mention the Interaction

Emodin … AZT can synergistically inhibit the proliferation, induce cell apoptosis, and down regulate the expression of NF-κB, BCL-2 and TGF-β mRNA and proteins … synergistic effect may be associated with inhibiton of BCL-2 activation and down-regulation of the expression of NF-κB, and TGF-β.
…Emodin … AZT can synergistically inhibit the proliferation, induce cell apoptosis, and down regulate the expression of NF-κB, BCL-2 and TGF-β mRNA and proteins … synergistic effect may be associated with inhibiton of BCL-2 activation and down-regulation of the expression of NF-κB, and TGF-β.
Zhongguo shi yan xue ye xue za zhi  •  2015  |  View Paper
The combination of emodin and AZT had considerable synergistic inhibitory effects on proliferation of normal KG-1a cells and nonspecific control(KG-1a NC) cells, but the synergistic effects disappeared after Egr-1 gene silencing.
The combination of emodin and AZT had considerable synergistic inhibitory effects on proliferation of normal KG-1a cells and nonspecific control(KG-1a NC) cells, but the synergistic effects disappeared after Egr-1 gene silencing.
Zhongguo shi yan xue ye xue za zhi  •  2015  |  View Paper
All examined combinations of AZT and emodin yielded a synergetic effect (CI < 1).
CONTEXT Previous studies have demonstrated that both 3'-azido-3'-deoxythymidine AZT ) and emodin , a traditional chemotherapy agent, can inhibit the growth of many types of cancer cells.
CONTEXT Previous studies have demonstrated that both 3'-azido-3'-deoxythymidine AZT ) and emodin , a traditional chemotherapy agent, can inhibit the growth of many types of cancer cells.
DISCUSSION AND CONCLUSION These results show a synergistic growth-inhibitory effect of AZT and emodin in K562/ADM cells, which is achieved through S phase arrest.
DISCUSSION AND CONCLUSION These results show a synergistic growth-inhibitory effect of AZT and emodin in K562/ADM cells, which is achieved through S phase arrest.
RESULTS The growth suppression of emodin was dramatically enhanced by AZT in K562/ADM cells.
RESULTS The growth suppression of emodin was dramatically enhanced by AZT in K562/ADM cells.
Pharmaceutical biology  •  2013  |  View Paper