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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Emodin
drug:
Zidovudine
Research Papers that Mention the Interaction
“Furthermore, the combination of emodin and AZT increased apoptosis in K562 cells (P<0.05).”
“The results demonstrated that AZT enhanced the inhibitory effect of emodin in K562 cells.”
Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.“… din co … ca n synergistically inhibit the proliferation, induce cell apoptosis, and down regulate the expression of NF-κB, BCL-2 and TGF-β mRNA and proteins in … of synergistic effect may be associated with inhibiton of BCL-2 activation and down-regulation of the expression of NF-κB, and TGF-β.”
“The combination of emodin and AZT had considerable synergistic inhibitory effects on proliferation of normal KG-1a cells and nonspecific control(KG-1a NC) cells, but the synergistic effects disappeared after Egr-1 gene silencing.”
“Abstract Context: Previous studies have demonstrated that both 3′-azido-3′-deoxythymidine AZT ) and emodin , a traditional chemotherapy agent, can inhibit the growth of many types of cancer cells.”
“All examined combinations of AZT and emodin yielded a synergetic effect (CI < 1).”
“Discussion and conclusion: These results show a synergistic growth-inhibitory effect of AZT and emodin in K562/ADM cells, which is achieved through S phase arrest.”
“Results: The growth suppression of emodin was dramatically enhanced by AZT in K562/ADM cells.”
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