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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Emodin and Sorafenib

supplement:

Emodin

Research Papers that Mention the Interaction

Animal models xenografted with HepG2 or SK-HEP-1 cells also showed that the combination of emodin and sorafenib was sufficient to inhibit tumor growth.
Furthermore, emodin synergistically increased cell cycle arrest in the G1 phase and apoptotic cells in the presence of sorafenib.
Here, we demonstrate that emodin significantly improved the anti-cancer effect of sorafenib in HCC cells, such as HepG2, Hep3B, Huh7, SK-HEP-1, and PLC/PRF5.
Overall, these results suggested that the combination of emodin and sorafenib may offer a potential therapy for patients with advanced HCC.
International journal of molecular sciences  •  2018  |  View Paper