Possible Interaction: Emodin and Recombinant Vascular Endothelial Growth Factor

“The antitumor function of emodin , attributed to the Notch signaling pathway, induced the downregulation of VEGF by suppressing tumorigenesis and angiogenesis, which indicated a novel mechanism underlying the emodin-mediated anti-prostate cancer effect.”

“The mRNA and protein expression of Notch1 … and protein expression levels of Jagged1, VEGF … emodin for 24 h. The LSCM assay revealed that the Notch1 was not only localized in the membrane … the PC3 cells, and the expression of Notch1 in the nuclei gradually increased following treatment with emodin.”

“ AE suppressed the nuclear translocation and DNA binding of NF-κB, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression.”

“Also, enzyme …) revealed that emodin significantly reduced the production of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-α), IL-…], mediators [prostagladin E(2) (PGE(2)), matrix metalloproteinase (MMP)-1 and MMP-13] and vascular endothelial growth factor (VEGF) as an angiogenesis biomarker in … LPS-treated synoviocytes under hypoxia.”

“Consistently, emodin attenuated the expression of cyclooxygenase 2 (COX-2), VEGF , hypoxia inducible factor 1 alpha (HIF-1α), MMP-1 and MMP-13 at mRNA level in IL-1β and LPS-treated synoviocytes under hypoxia.”

“In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner.”