supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Emodin
drug:
Probenecid
Research Papers that Mention the Interaction
“In toxicokinetics‐toxicodynamics (TK‐TD) study, aspartate aminotransferase (AST) and systemic exposure (area under the serum concentration‐time curve, AUC) of emodin and its glucuronide were significantly increased in rats after co‐administrated with emodin and probenecid for 28 consecutive days.”
“ Probenecid inhibits UGTs and MRP2 and thus exacerbates emodin hepatotoxicity.”
Emodin‐induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback