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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Emodin and Piperine



Research Papers that Mention the Interaction

As the in vivo pharmacokinetic studies had indicated, the AUC and Cmax of emodin were increased significantly after piperine treatment, and the glucuronidation of emodin was markedly inhibited.
Further research is needed to investigate the detailed mechanism of improved bioavailability of emodin via its combination with piperine.
In this study, piperine , as a bioenhancer, was used to enhance the bioavailability of emodin by inhibiting its glucuronidation.
Our study demonstrated that piperine significantly improved the in vivo bioavailability of emodin and the influence of piperine on the pharmacokinetics of emodin may be attributed to the inhibition of glucuronidation of emodin.
Journal of pharmaceutical and biomedical analysis  •  2015  |  View Paper