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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Emodin and Interleukin-10

supplement:

Emodin

Research Papers that Mention the Interaction

As to septic PBMC, emodin significantly stimulated TNF-alpha and IL-10 release and SMI significantly increased the concentration of TNF-alpha in the SS patients.
Emodin could significantly decrease the level of IL-10 , and SMI recovered TNF-alphareleasing and had no effect on IL-10.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine  •  2006  |  View Paper
In addition, emodin significantly reduced ConA-induced nitric oxide (NO) production and the formation/release of TH1 (IL-2, IFNγ, TNFα) and TH17 (IL-6 and IL-17) cell cytokines, but induced those of TH2 (IL-4) and Treg ( IL-10 ) cells.
Journal of immunotoxicology  •  2016  |  View Paper
It was found that a treatment of 20 microg/ml emodin inhibited the expression of a panel of inflammatory-associated genes, including TNFalpha, iNOS, IL-10 , cytosolic IkappaBalpha, IKK-alpha and IKK-gamma, to different extents as well as the nuclear translocation of NF-kappaB (nuclear factor-kappaB).
International journal of molecular medicine  •  2005  |  View Paper