“After treatment of emodin and imatinib together, the levels of p-Bcr-Abl and Bcr-Abl were significantly downregulated.”
“ Emodin greatly enhanced cell sensitivity to imatinib , suppressed resistant cell proliferation and increased potentiated apoptosis induced by imatinib in K562/G01 cells.”
“Overall, these data indicated emodin might be an effective therapeutic agent for inhibiting resistance to imatinib in CML treatment.”