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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Emodin and Glucose





Research Papers that Mention the Interaction

These adverse effects of high glucose could be prevented to a large extent by co-culture with 3 μM of emodin which per se did not affect HUVECs viability.
Biochemical pharmacology  •  2015  |  View Paper
Synthesis of FN induced by high glucose was also reduced by 40% in the presence of emodin.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis  •  2001  |  View Paper
Treatment with emodin significantly turns down the accelerated cell cycle and proliferation of MCs cultured in high glucose (HG) via inhibiting cFLIP.
PloS one  •  2014  |  View Paper
Besides, emodin and PERK knockdown inhibited the apoptosis of podocytes cultured in high glucose by counteracting the upregulation of phosphorylated PERK, phosphorylated eIF2α, ATF4, and CHOP.
Drug design, development and therapy  •  2018  |  View Paper
Also, emodin inhibited glucose production by suppressing the expression of key gluconeogenic genes, such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, in hepatocytes.
Finally, we confirmed that a single dose administration of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance in C57Bl/6J mice.
The Journal of Biological Chemistry  •  2013  |  View Paper
Emodin 0.2, 0.4, 0.8, and 1.6 g/L decreased PD when there was glucose.
World journal of gastroenterology  •  2005  |  View Paper