Possible Interaction: Emodin and Doxorubicin Hydrochloride

“… emodin , via ROS-related mechanism and suppressing the function of ATP-binding cassette super-family G member (ABCG2), which is known to be associated with … only reduced the ratio, inhibited clone formation, and eliminated sphere formation of SP cells effectively, but also promoted obviously the intracellular accumulation of doxorubicin, ….”

“Treatment with doxorubicin dox ) and emodin , separately and together, under normoxic and hypoxia-like conditions induced by CoCl2, led to greater intracellular compound accumulation over 10 h post-addition in the presence of CoCl2 in lung adenocarcinoma (A549) and colorectal carcinoma (HCT-15) cell lines.”

“The treatment of Raji cells with emodin combined with doxorubicin led increased cell death of Raji cells, indicating that emodin may sensitize Raji cells to doxorubicin-induced apoptosis.”

“Results: The results showed that after administration of Dox (10µM) with different concentrations of Emodin , the cells exhibited a dose-dependent inhibition action to H69AR cells at 48 hours.”

“The expression of Twist, Snail, and Slug can be effectively inhibited by combination of Dox and Emodin.”

“Furthermore, the addition of emodin enhanced ADR and DNR intracellular accumulation and subcellular distribution in HL-60/ADR cells in dose-dependent manner.”

“When emodin was added to the cell culture at the concentration of 10 μg/ml, the drug resistance was reduced from 21 folds to 2.86 folds for adriamycin , and from 11 folds to 1.79 folds for cisplatin.”

“Furthermore, the combination of emodin with cisplatin, doxorubicin or etoposide (VP16) synergistically inhibited the proliferation of HER-2/neu-overexpressing lung cancer cells, whereas low doses of emodin, cisplatin, doxorubicin, or VP16 alone had only minimal antiproliferative effects on these cells.”

“ Emodin , a CSNK2A1 inhibitor, potentiated the cytotoxic effects of doxorubicin in osteosarcoma cells.”

“Here, we interrogate the role of Emodin , a chemical compound with tumor inhibitory properties, in the resistance of BC to Doxorubicin.”

“Taken together, our data demonstrates that Emodin affects cell proliferation, and DNA damage pathways in BC cells, thus increasing the sensitivity of BC cells to doxorubicin.”

“ AE can also enhance the anticancer efficacy of cisplatin, doxorubicin , docetaxel, and 5-fluorouracil; however, its effects remain poorly characterized.”