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Last Updated: 2 months ago

Possible Interaction: Emodin and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

The treatment of Raji cells with emodin combined with doxorubicin led increased cell death of Raji cells, indicating that emodin may sensitize Raji cells to doxorubicin‑induced apoptosis.
Molecular medicine reports  •  2017  |  View Paper
RESULTS The results showed that after administration of Dox (10µM) with different concentrations of Emodin , the cells exhibited a dose-dependent inhibition action to H69AR cells at 48 hours.
RESULTS The results showed that after administration of Dox (10µM) with different concentrations of Emodin , the cells exhibited a dose-dependent inhibition action to H69AR cells at 48 hours.
The expression of Twist, Snail, and Slug can be effectively inhibited by combination of Dox and Emodin.
Cellular Physiology and Biochemistry  •  2017  |  View Paper
Furthermore, the addition of emodin enhanced ADR and DNR intracellular accumulation and subcellular distribution in HL-60/ADR cells in dose-dependent manner.
Zhongguo shi yan xue ye xue za zhi  •  2013  |  View Paper
When emodin was added to the cell culture at the concentration of 10 μg/ml, the drug resistance was reduced from 21 folds to 2.86 folds for adriamycin , and from 11 folds to 1.79 folds for cisplatin.
Journal of Translational Medicine  •  2012  |  View Paper
Furthermore, the combination of emodin with cisplatin, doxorubicin or etoposide (VP16) synergistically inhibited the proliferation of HER-2/neu-overexpressing lung cancer cells, whereas low doses of emodin, cisplatin, doxorubicin, or VP16 alone had only minimal antiproliferative effects on these cells.
Oncogene  •  1996  |  View Paper
AE can also enhance the anticancer efficacy of cisplatin, doxorubicin , docetaxel, and 5-fluorouracil; however, its effects remain poorly characterized.
The American journal of Chinese medicine  •  2017  |  View Paper
However, in the myeloid cell lines the effects of the combination treatments varied; doxorubicin had a synergistic or additive effect when combined with quercetin, apigenin, emodin , and cis-stilbene, but had an antagonistic effect when combined with rhein.
Cell Death Discovery  •  2015  |  View Paper
emodin , via ROS-related mechanism and suppressing the function of ATP-binding cassette super-family G member (ABCG2), which is known to be associated with … only reduced the ratio, inhibited clone formation, and eliminated sphere formation of SP cells effectively, but also promoted obviously the intracellular accumulation of doxorubicin, ….
Stem cells and development  •  2013  |  View Paper