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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Emodin
drug:
Dopachrome Isomerase
Research Papers that Mention the Interaction
“Tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 mRNA levels decreased following emodin treatment.”
Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.“Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2 , MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence.”
“Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2 , tyrosinase through the activation of MITF transcription factor.”
The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway.
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