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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Emodin
drug:
Arsenic Trioxide
Research Papers that Mention the Interaction
“Oxidative stress caused by emodin , an ROS producer, in combination with arsenic trioxide ( ATO ) led to RhoA inactivation that triggered structural disruption of focal adhesion complex and eventually resulted in anoikis, and these effects could be partially reversed by antioxidant N-acetylcysteine (NAC).”
Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis.“In this study we report a potent synergistic effect of the combination of arsenic trioxide and interferon alpha (As/IFN-alpha) with emodin and DHA on cell-cycle arrest and cell death of HTLV-I-infected cells.”
“The results demonstrated that coadministration of emodin , at low doses of 0.5–10 μm, with As2O3 enhanced As2O3-rendered cytotoxicity on tumor cells, whereas these treatments caused no detectable proproliferative or proapoptotic effects on nontumor cells.”
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