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Last Updated: 2 years ago

Possible Interaction: Ellagic Acid and Warfarin

supplement:

Ellagic Acid

Research Papers that Mention the Interaction

Pomegranate peel extract showed insignificant effects on warfarin pharmacokinetics (p > 0.05), however, its constituent, namely, ellagic acid significantly increased warfarin Cmax (p < 0.05).
ResultsPreparations of pomegranate peel guava leaf extract, ellagic acid and quercetin in combination with warfarin were found to exert further significant increase on PT and INR values (p < 0.01) than when used alone (p < 0.05).
Significant reduction in CYP2C8, 2C9, and 3A4 was seen upon concomitant use of warfarin with ellagic acid , guava leaves and quercetin, unlike pomegranate that insignificantly affected CYP activities.
BMC Complementary and Alternative Medicine  •  2019  |  View Paper