Allen Institute for Artificial Intelligence
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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Ellagic Acid and O(6)-Benzylguanine

Research Papers that Mention the Interaction

HPLC analysis of DNA hydrolysates showed that ellagic acid caused a dose-dependent 36-84% decrease in O6-methylguanine but only a 20% decrease in the 7-methylguanine adduct.
Proceedings of the National Academy of Sciences of the United States of America  •  1986  |  View Paper
In some model systems, EA has been reported to selectively decrease the mutagenic DNA adduct O6-methylguanine ( O6MG ) when compared to the cytotoxic DNA adduct N7-methylguanine (N7MG).
Teratology  •  1993  |  View Paper
EA caused a dose-dependent decrease in the formation of N7-methylguanine and O6-methylguanine adducts.
Carcinogenesis  •  1988  |  View Paper