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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Ellagic Acid
drug:
O(6)-Benzylguanine
Research Papers that Mention the Interaction
“HPLC analysis of DNA hydrolysates showed that ellagic acid caused a dose-dependent 36-84% decrease in O6-methylguanine but only a 20% decrease in the 7-methylguanine adduct.”
Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.“In some model systems, EA has been reported to selectively decrease the mutagenic DNA adduct O6-methylguanine ( O6MG ) when compared to the cytotoxic DNA adduct N7-methylguanine (N7MG).”
Ellagic acid embryoprotection in vitro: distribution and effects on DNA adduct formation.“ EA caused a dose-dependent decrease in the formation of N7-methylguanine and O6-methylguanine adducts.”
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