Possible Interaction: Ellagic Acid and Nitric Oxide

“Besides, EA significantly improved nitric oxide synthase activity, antioxidant capacity and markers of endothelial dysfunction in plasma.”

“Our data indicate that ellagic acid exerts its protective effects by inhibiting NADPH oxidase-induced overproduction of superoxide, suppressing the release of NO by down-regulating iNOS, enhancing cellular antioxidant defenses, and attenuating oxLDL-induced LOX-1 up-regulation and eNOS down-regulation.”

“Results showed that EA dose dependently provoked antidepressant-like effects and also decreased the hippocampal NO level as well as expression of NMDA-Rs.”

“Elevated levels of malondialdehyde (MDA) and nitric oxide (NO) in renal and hepatic tissue was reduced by EA treatment (all p<0.001).”

“In conclusion, ellagic acid attenuates hypertension, possibly improving nitric oxide bioavailability.”

“The present study discloses that EA suppresses HO‐1 and, its renoprotection is also linked to its anti‐inflammatory and antiapoptotic properties, as well as the reduction of nitric oxide and endothelin‐1.”

“However, MDA, TOS, OSI, and NO levels were found to be significantly reduced in the ellagic acid-treated diabetic group compared to the untreated diabetic group in these tissues (for both parameters, p < 0.05).”

“Administration of EA and/or PSO decreased the intestinal damage, PGE2, MDA and NO levels and MPO, XO and AD activities and increased GSH level.”

“ EA significantly improved the status of antioxidants and decreased TBARS, hydroperoxides, NO , PCC and liver marker enzymes at the dose of 60 mg/kg body weight when compared with the alcohol-treated group.”

“ EA exposure alleviated the developmental malformations observed in treated embryos and decreased the levels of SA and NO in those same embryos.”