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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Ellagic Acid
Research Papers that Mention the Interaction
“CONCLUSION We discovered that EA sy nergistically potentiated DOX an d DDP in suppressing HCC with significantly reduced side effects and this may represent a novel strategy in HCC therapies with both high anticancer efficiencies and low systemic toxicity in patients.”
“RESULTS EA co uld both markedly potentiate anticancer activities of DOX an d DDP to HCC HepG2 and SMMC-7721 cells, and reduce their cytotoxicity to normal liver HL-7702 cells.”
Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma.“Application of ellagic acid to rats pre-treated with doxorubicin significantly prevented functional changes occurring in the heart, but not in the thoracic aorta tissue.”
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model.“Interestingly, mitochondrial associated Bnip3 in cells treated with doxorubicin was markedly reduced by EA.”
“ Ellagic acid dose-dependently lowered caspase-3 activity and cleaved … % declined activity and protein level of NF-κB. Doxorubicin treatment also up-regulated cardiac expression of p-p38, p-ERK 1/2 and p-JNK, … % suppressed p-p38 expression and at 1 % down-regulated p-ERK 1/2 expression.”
“These findings suggest that ellagic acid is a potent cardiac protective agent against doxorubicin.”
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