Possible Interaction: Eicosapentaenoic Acid and Vitamin E

“The effects of EPA on Raji cells were counteracted by vitamin E , indicating that l ipid peroxidat ion may be involved.”

“Both inhibition of the COX pathway by indomethacin as well as inhibition of direct lipid peroxidation by antioxidants such as vitamin E and C diminished the anti-proliferative effects of AA as well as EPA.”

“ alpha-Tocopherol suppressed cytotoxicity of CEPA and CDHA in tumor cells, and the cytotoxicity involved membrane phospholipid peroxidation.”

“Although not significantly different between groups, DHA supplementation decreased total glutathione in plasma (P<0.05) and EPA supplementation increased plasma concentration of vitamin E (P<0.05).”

“The effects of EPA on Raji cells, was counteracted by vitamin E , indicating that lipid peroxidation was involved.”

“The action of EPA could be reversed with the anti-oxidant vitamin E acetate or with oleic acid.”

“GLA, EPA , and DHA-induced free radical generation and lipid peroxidation were also inhibited by vitamin E and SOD.”

“On the other hand, the anti-oxidant, vitamin E , and the superoxide anion quencher, superoxide dismutase (SOD), could completely inhibit the cytotoxic action of GLA, EPA and DHA indicating a role for free radicals and, in particular, the superoxide anion in this process.”

“Addition of vitamin E decreased the effects of GLA and EPA , which supports the hypothesis of direct action by these fatty acids.”

“Interestingly, EPA prevented the alpha-tocopherol level from falling and the overall lipid peroxidation from increasing as it did during diamide treatment.”

“Besides, the combination of EPA with VE or CYS reduced the percentages of MI oocytes after 24 h of IVM (P < 0.05).”