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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Eicosapentaenoic Acid
drug:
Simvastatin
Research Papers that Mention the Interaction
“In addition, simvastatin increased the AA: EPA ratio from 15.5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053).”
Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients.“In the monocytic THP-1 cells, the …-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor simvastatin (5 microM) enhances the conversion … (18:2 n-6) and eicosapentaenoic (20:5 n-3) acids to their long-chain polyunsaturated fatty acid (…, and this effect is associated with changes in the desaturation steps.”
“Crucially, while simvastatin reduced PrPSc formation, both DHA and EPA significantly increased the amounts of PrPSc in these cells.”
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
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