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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Eicosapentaenoic Acid
drug:
Ribavirin
Research Papers that Mention the Interaction
“CONCLUSION EP ca n decrease the rate of RBV do se reduction and RBV-induced hemolysis during the course of combination treatment.”
Can eicosapentaenoic acid maintain the original ribavirin dose or affect the response during the treatment course of chronic hepatitis C virus (HCV) patients?“Conclusion: EPA could prevent the RBV dose reduction during the first 12 weeks in combination therapy, although further large-scale double-blind randomized controlled trials are required.”
“However, in the multivariate analysis, treatment with EPA showed significant variables for the reduction of RBV dose (odds ratio 3.235, p = 0.023).”
“Results: 8 patients (17%) in the EPA group and 20 patients (29%) in the non-EPA group required RBV dose reduction, respectively.”
“The cumulative RBV reduction rate was significantly lower in the EPA group than in the non-EPA group (p = 0.017), while the decrease of hemoglobin and RBV plasma concentrations from baseline was not significantly different.”
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