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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Eicosapentaenoic Acid
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“Supplementation of n-3 PUFA for 6 months resulted in a significant increase in concentrations of eicosapentaenoic and docosahexaenoic acids in red blood cells along with an attenuation of hepatic steatosis as reflected by the reduction of the FLI, ALT and ALT/AST ratio.”
Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids.“We investigated whether short term intravenous supply of omega-3 PUFAs could change the levels of EPA , DHA, ARA and linoleic acid in plasma and erythrocytes in patients with hepatic colorectal metastases.”
“Supplementation with the PUFA led to a substantial increase in the proportions of EPA , DHA, and α-tocopherol in the plasma phospholipids and red blood cell (RBC) total lipids, but an increase was noted in the plasma phospholipid proportions of 18∶3n-3 with olive oil as well.”
“n-3 PUFA treatment increased EPA and DHA concentrations in RBC membranes in a time-dependent manner in all of the n-3 PUFA groups.”
“Increasing dietary n-3 PUFA intake results in increased DHA and EPA content in cell membranes as well as an increase in n-3 derived oxylipin and -endocannabinoid concentrations, like fatty acid amides and glycerol-esters.”
“Acute perfusion of either PUFA slowed the activation kinetics and EPA shifted the activation curve to the left.”
“AA and EPA are precursors of different classes of pro-inflammatory or anti-inflammatory eicosanoids, respectively, whose biological activities have been evoked to justify risks and benefits of PUFA consumption.”
“ Eicosapentaenoic acid suppressed LC-PUFA synthesis in AS cells and also suppressed activity of the salmon Delta6 FAD promoter although this activity was likely mediated through sites other than Sp1, possibly similar to those recognised by NF-Y and SREBP transcription factors.”
“For instance, n‐3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic and docosahexaenoic acids are preferentially oxidizied to other PUFA but results remain inconsistent.”
“Dietary n-3 PUFAs increased the cardiac content of eicosapentaenoic and docosahexaenoic acid.”
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